Favorite Quote from a Game or Movie

"Made it, Ma! Top of the world!"
-Cody Jarett (James Cagney), White Heat

If visual novels count, here's a great one from Saya no Uta:

 Spoiler

Your princess is in another castle! - Super Mario Bros
The cake is a lie - Portal
All your base are belong to us - Zero Wing
I've got balls of steel - Duke Nukem 3D
The master of Un-locking - Resident Evil

Destruct, prove us that now is the hour of our reckoning (Sands of destruction/Wolrd destruction)
Im agan the green.....................................and red(^ same)
A horse weiner? NOW THATS DANGEROUS!!! (Disgaea)

"Don't blame us, blame yourself or God." -Delita in the original Final Fantasy Tactics

ITS THE COLE TRAIN bABY WOOOOOOOOO!!!!

COLE TrAIN IS A SMOoOOoTHHH RIDEEEE BABY.

ROOKIE ThIS AINT THE BIG GAME YET! SAVE YO ASS FOR THE PLAYOFFS WOOOOOOO!

HAHA IN THE FLeSH BABY, WHATS uP BEACHES!?

HEY DOnT TALK ABOUT BAIRD LIKE THAT MAN, ITS HaRD BEING BLOND AND STUFF WOOOoOOOOO!

"If I could go back in time... I'd wanna meet snoopy."

Melody, Josie and the Pussycats

Adrian Veidt: I've made myself feel every death... see every innocent face I've murdered to save humanity.
[Turns to Jon]
Adrian Veidt: You understand, don't you?
Jon Osterman: Without condoning... or condemning. I understand.

Bwahahaha just watched Scarface

'Say hello to my little friend' -kaboom- +_+

Gotta love a classic line.