2011-05-16, 02:35 AM
To scientists, a year old new is still fairly recent.
I saw that flawed statement when I was searching for blog posts on this topic, and I left that page immediately. Not authoritative.
I'd like to see what happens if you tried to activate you mitochondria right now in the context of this topic. Cytochrome C release leading to the formation of Apoptosome, and thus activation of Caspases and death effectors. In short, you die.
I also note that cancer is a hell lot more complex than most people would ever think. You should see the review paper "The Hallmarks of Cancer: The Next Generation" published very recently (i.e. 1/2 months ago) arguing how neoplasia is a multifactorial complex disorder. Pretty good paper, and in there the Warburg effect was mentioned as well (obviously).
So what's my take? My take is: find out how it works and find any possible side effects in vivo and in vitro while doing clinical studies (side effect studies are part of clinical trials). Don't rush things just because it looks promising *looks at Thalidomide*. As a perspective, you think big pharmas are making big money? Oh yes they do, but what's the cost that they're paying? Out of all the R&D [in billions] that goes in, an average of 10% comes out as "successful products".
Hadriel
I saw that flawed statement when I was searching for blog posts on this topic, and I left that page immediately. Not authoritative.
I'd like to see what happens if you tried to activate you mitochondria right now in the context of this topic. Cytochrome C release leading to the formation of Apoptosome, and thus activation of Caspases and death effectors. In short, you die.
I also note that cancer is a hell lot more complex than most people would ever think. You should see the review paper "The Hallmarks of Cancer: The Next Generation" published very recently (i.e. 1/2 months ago) arguing how neoplasia is a multifactorial complex disorder. Pretty good paper, and in there the Warburg effect was mentioned as well (obviously).
So what's my take? My take is: find out how it works and find any possible side effects in vivo and in vitro while doing clinical studies (side effect studies are part of clinical trials). Don't rush things just because it looks promising *looks at Thalidomide*. As a perspective, you think big pharmas are making big money? Oh yes they do, but what's the cost that they're paying? Out of all the R&D [in billions] that goes in, an average of 10% comes out as "successful products".
Hadriel