Original General Dungeon Fighter Thread

Striker Guide. It's a bit outdated but it will give you a general idea of what skills you need and some basic combos.

Here is a complete fighter guide, you might find some useful information here.

As for hotkeys, you generally want to hotkey moves that have complex inputs and input moves with simple inputs. Higher level skills usually have complex inputs, so it wouldn't hurt to learn the inputs of the more basic skills. Hammer Kick is a move I usually input since it's just Up (while holding) + Z. Just remember, the most important thing for hotkeys is picking a layout that is comfortable and accessible for you, don't be afraid to more around hotkeys and skills.