Will these parts work together?

From what the specs state, it is capable of running 1 PCI-E x16 at x16, and the other at x4. The problem is, though, will the two run together without CrossFire? I've personally never used more than 1 PCI-E x16 slot at once, and all of the computers that I own only have 1. My guess is that they will probably run, but might want to make sure beforehand.

Booting will probably be fine (99%+), BIOSs allow you to boot from bootable add in cards after all (and the fact that the card would have almost no appeal if you couldn't boot off of it).