Spam Panic or Power Strike?

I would say that at bosses, charging orbs + panic would be better than Power strike with full orbs as many of the bosses out there dispel. Then again, the statistics prove that orbs + panic does more damage.

Mushmom, zmm, bmm, jrog, etc: Not enough hp to really matter. By the time you charge up your orbs, they're dead.

Papulatus/Left Fish/Manon and Griffey: Dispel so your PS damage would be even lower as you constantly have to recharge.