The Binding of Isaac: Rebirth

Soy Milk then Libra is the best combo ever. Soy Milk's massive damage reduction is reverted but you keep your tear speed. It's ridiculously OP, but you need to get Libra after you get Soy Milk or it doesn't work.

I never get Chocolate Milk unless I have low tears as it is...so I never grab it. I have more problems getting Ludivico Technique, and I always do terrible with it in the end.

I've heard about that, but the problem with that is you have to rely on finding Libra soon after or your run is most likely doomed...

I'm neutral on Ludo. Sometimes it can be great, other times... not so great. If you could still use the mouse to control your tears I imagine it wouldn't be quite as bad.