The Binding of Isaac: Rebirth

pineapple spiders of all kinds.
The tiny ones that move annoyingly fast and rush at you in sudden bursts
the big ones that do the exact same thing but then split into 2 more of the little fuckers
the tall ones that spawn out little ones that take forever to kill
the jumping ones
the fucking bomb ones
and especially the ones that climb on the fucking walls, AND ESPECIALLY the ones that fire brimstone beams.

Love the game, but that entire enemy type just annoys me to no end.
Getting the Cellar instead of the basement is like torture.