Especially with the N3DS. The game feels a lot smoother with the improved hardware, and anyone who had an issue with the sweet spot 3D before will like the new and improved 3D, although it can lose track of you which basically blinds you. I'm hoping some future firmware upgrades will refine it. The C-Stick is weird to use (It doesn't move. It's just a nub that senses pressure), but I never used the extra analog that much anyway (I use the hell out of ZL and ZR for horizontal camera movement, especially with Bow). It takes getting used to, because ZL and ZR are inward from L and R, which is different and at first it's easy to accidentally press the wrong one. It's also nice to have Start+Select where they should have been in the first place, although easy to forget they're there now since the 3DS had them in the wrong spot for so long.
I don't have any problem with where the power button is, because it requires an immense amount of pressure to hit, so there's almost no chance of hitting it accidentally, however I don't feel the same way about the game cart. My pinky goes there naturally and I feel like I'm going to accidentally push out the cart at any time. I have to consciously move my pinky whenever I adjust how I'm holding it. Probably my biggest issue with the N3DS.
Some Game Impressions, though mostly weapon related
My friend, who mains Charge Axe, said that they improved everything about the weapon including adding several new combos and overall completely increasing its damage.
I haven't gotten a chance to check out any melee weapon changes yet, though, as my Blademaster set was completely obliterated in the import and I have no intention of getting a new one without it being G Rank and having Sharpness+1, so it might be a while. My old set went from Sharp+1, Evade+1 and Crit Eye+1 to Crit Eye+1 with lower defense than it had before. It's completely useless now and I'm not going to work on making it functional.
However, they made it so that Bow's aim vertical is kept between aims, which is a HUGE improvement because there were issues in MH4 where you'd have to aim down constantly because you're at the top of a hill ([or vice versa]since they went crazy with the Y axis on maps), and you would spend more time aiming then it took to charge, which also took away your ability to move while charging. It's a small change that makes the weapon so much better to use in those areas.
If anyone has any questions, I'll be happy to answer if I can.