So I'm watching Transformers: Beast Machines, and

>see Megatron
>Megatron is in a control harness
>he controls the entire planet
>before he came into power he wiped out the planet with a virus
>has an assistant with a single eye shaped like a sphere
>

 portal 2 spoiler

becomes fully made of technology from being part organic

>GLaDOS
>GLaDOS is in a control room similar to Megatron
>she controls the entire test facility
>before she came into power she killed everyone in the facility with neurotoxin
>has single eye sphere shaped robot test subject
>

 portal 2 spoiler

becomes a computer after being a human

holy s'hit, GLaDOS is Megatron's birthchild

But since That Megatron came from the future (iirc they're the descendent from the original ones, autobots and decepticons) maybe he's GLaDOS birthchild.