KajitiSouls Wrote:I live in my own world, and I have a limited IP budget. If you gift me Alistar, then I shall oblige. Otherwise nothnx, I have no incentive to try out someone that doesn't look like I would have fun to begin with.

Quote:ScienceDaily (Apr. 28, 2011) — Using advanced DNA analysis and extensive field work, an international research team has confirmed the link between leprosy infection in Americans and direct contact with armadillos. In a joint collaboration between the Global Health Institute at EPFL in Switzerland and Louisiana State University, clear evidence was found that a never-before-seen strain of Mycobacterium leprae has emerged in the Southern United States and that it is transmitted through contact with armadillos carrying the disease. The results will be published on April 28th in the New England Journal of Medicine.

There are only around 150 cases of leprosy in the United States each year. Most of these victims have worked abroad in areas in which leprosy is endemic, making it likely that they may have acquired the disease while outside the US. But, to the alarm of health authorities, a third of all patients infected appear to have contracted the disease locally. The hypothesis that the disease is transmitted though contact with armadillos -- aside from humans, the only other known carriers of the leprosy-causing bacteria -- was confirmed by fine-grained DNA analysis of both armadillo and human samples done at EPFL.

Leprosy bacilli found in armadillos

It has been known since the 1970s that armadillos are potential carriers of the disease, most likely introduced by European immigrants 500 years ago. But the current study shows inter-species contamination and the presence of a unique strain. "There is a very strong association between the geographic location of the presence of this particular strain of M. leprae and the presence of armadillos in the Southern US," explains Stewart Cole, head of the Global Health Institute in Lausanne and world-leader in the field of genomics of leprosy bacilli. "Our research provides clear DNA evidence that the unique strain found in armadillos is the same as the one in certain humans."

The study included 33 wild armadillos known to have the disease and 50 leprosy patients. The new strain of the bacteria, named 3I, was found in 28 armadillos and in 22 patients who reported no foreign residence. The researchers used genome sequencing to identify the new strain and cross check it with other known strains from Europe, Brazil and Asia, and used genotyping to identify and classify the population infected. It became clear that leprosy patients who never travelled outside the US but lived in areas where infected armadillos are prevalent were infected with the same strain as the armadillos. These findings prompted the researchers to state in the article that "Frequent direct contact with armadillos and cooking and consumption of armadillo meat should be discouraged." The study also suggests that armadillo range expansion should be monitored.

It is not known exactly why armadillos contract and carry leprosy. While their low body temperature (89° F / 32° C) makes them perfect incubators for the bacteria, which grow in temperatures between 86° F and 89° F (30° C to 32° C), there are almost certainly other factors such as immune deficiency that also play a role. Similarly, the bacteria attack the extremities of humans because our core body temperature is too high for a generalized infection, and over 90% of humans who come into direct contact with the disease spontaneously fight it off. "The last thing we want is to induce panic in the population and incite a slaughter of armadillos. The best way to combat further infection is though education and prudence," says Cole.

The stigma of leprosy

José Ramirez, a former migrant worker from Houston who contracted the disease after hunting and eating armadillo meat and took part in the study, has consecrated his life to combating social stigmas. He hopes that the study brings to light the stigma attached to leprosy. "We need to take this opportunity to give leprosy patients a voice and to learn to not use the word 'leper' that has negative connotations around the world, a stigma that should be replaced with an understanding of the disease and its causes." Ramirez, who struggled over five years with the disease before it was properly diagnosed, is now disease-free after receiving antibiotic treatment. Proving what few know to be true -- that leprosy is a bacterial infection that can be cured.

>Pineapple' Wrote:I guess I can't play my favorite armordillo anymore....

not ok

Dark Link Wrote:So I've wondered about something, when the jungler requests a gank in the lane I'm in, such as they're in the brush waiting, who initiates? The laner or the jungler?

Quote:Disclaimer: >Pineapple beat me to calling out Rammus.

Duelman Wrote:Don't knock it till ya try it! If they had a gift system I would do it just to make you play him with me.

Next time he's free you'll give him a chance eh?

Dark Link Wrote:So I've wondered about something, when the jungler requests a gank in the lane I'm in, such as they're in the brush waiting, who initiates? The laner or the jungler?

 Spoiler

Unleashing Wrote:

Talking of rammus.
Has he been nerfed as of late?

Kalas Wrote:I wouldn't say MF is a viable carry at the moment, shes been nerfed to hard from the past and with all the tanky dps with gap closers it is so easy to kill her.

The only time its worth playing her is to troll by stacking tiamats and spamming double up.

Phoenix Wright Wrote:Speaking of which...